IEEE System, Man, and Cybernetics Society announces the 21st International Conference on System of Systems Engineering (SoSE) with its vast ramifications in numerous engineering fields such as control, computing, communication, information technology, artificial intelligence, and in applications such manufacturing, defense, national security, aerospace, aeronautics, energy, environment, healthcare, and transportation. The conference theme is “The World as Systems of Systems”. Papers on theories, methodologies, and applications of System of Systems Engineering in science, technology, industry, and education are welcome.